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ea0034p307 | Pituitary | SFEBES2014

The incidence of hypopituitarism in post interventional subarachnoid haemorrhage (SAH) survivors in a tertiary neurosurgical unit

McGlynn Stephen J , Cox Joanna , Giritharan Sumi , Gnanalingham Kanna , Hughes David , Sheldrick Russell , Kearney Tara M

Background: SAH is a significant cause of morbidity and mortality. Survivors report long term psychological distress, sleep disturbance, libido changes and fatigue. Previous studies describe an increased incidence of hypopituitarism.Hypothesis: Evaluation of psychological symptoms and clinical and radiological features of SAH could predict the incidence of hypopituitarism.Patients and Methods: 102 post-interventional SAH survivors ...

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ea0034p308 | Pituitary | SFEBES2014

Inhibition of lipolysis improves peripheral and hepatic insulin sensitivity and restores first phase insulin response in patients with acromegaly

McGlynn Stephen J , Bluck Les , Salgin Burak , Trainer Peter J , Williams Steve , Higham Claire E

Acromegaly causes impaired insulin sensitivity and reduced fat mass. Using acipimox to block lipolysis, the impact of free fatty acids (FFA) on insulin sensitivity in active acromegaly was investigated. 1H MRS was used to quantify triglyceride (TG) content of liver and muscle.Methods: 6 patients with active acromegaly (AA) (5M, age 59 (3470), IGF-I (ng/ml) (median (range)) (452 (3421002)) were studied on 2 visits; (i) baseline (BL)...

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Endocrine Abstracts

The incidence of hypopituitarism in post interventional subarachnoid haemorrhage (SAH) survivors in a tertiary neurosurgical unit

Inhibition of lipolysis improves peripheral and hepatic insulin sensitivity and restores first phase insulin response in patients with acromegaly

BiosciAbstracts